Otay Mesa is just east of San Ysidro off the 905 cut-off (from the 5 and 805 freeways). Although passenger vehicles may cross at Otay Mesa, it is where all commercial goods are crossed. This border crossing is open also 24 hours for cars. For commercial vehicles the hours are from 9:00 a.m. to 8:00 p.m. Monday through Friday, and 9:00 to 11:00 a.m. on Saturday.

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